Type II Binders Targeting the “GLR-out” Conformation of the Pseudokinase STRADα

Pseudokinases play important roles in signal transduction and cellular processes similarly to catalytically competent kinases. However, pseudokinase pharmacological tractability and conformational space accessibility are poorly understood. Pseudokinases have only recently been suggested to adopt “in...

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Vydáno v:Biochemistry
Hlavní autoři: Smith, Ryan H.B., Khan, Zaigham M., Ung, Peter Man-Un, Scopton, Alex, Silber, Lisa, Mack, Seshat M., Real, Alexander, Schlessinger, Avner, Dar, Arvin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995334/
https://ncbi.nlm.nih.gov/pubmed/33440120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00714
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