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Redefining the protein kinase conformational space with machine learning
Protein kinases are dynamic, adopting different conformational states that are critical for their catalytic activity. We assess a range of structural features derived from the conserved αC-helix and DFG-motif to define the conformational space of the catalytic domain of protein kinases. We then cons...
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| 發表在: | Cell Chem Biol |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6054563/ https://ncbi.nlm.nih.gov/pubmed/29861272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.05.002 |
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