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Redefining the protein kinase conformational space with machine learning
Protein kinases are dynamic, adopting different conformational states that are critical for their catalytic activity. We assess a range of structural features derived from the conserved αC-helix and DFG-motif to define the conformational space of the catalytic domain of protein kinases. We then cons...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6054563/ https://ncbi.nlm.nih.gov/pubmed/29861272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.05.002 |
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