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A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space
Synthetic tailoring of approved drugs for new indications is often difficult, as the most appropriate targets may not be readily apparent and therefore few roadmaps exist to guide chemistry. Here, we report a multidisciplinary approach for accessing novel target and chemical space starting from an F...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931369/ https://ncbi.nlm.nih.gov/pubmed/29355849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2556 |
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