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Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling
Deregulation of the Ras–mitogen activated protein kinase (MAPK) pathway is an early event in many different cancers and a key driver of resistance to targeted therapies(1). Sustained signalling through this pathway is caused most often by mutations in K-Ras, which biochemically favours the stabiliza...
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| Publicado no: | Nature |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161575/ https://ncbi.nlm.nih.gov/pubmed/27556948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19327 |
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