Structural basis for the action of the drug trametinib at KSR-bound MEK

The MAPK/ERK Kinase MEK is a shared effector of the frequent cancer drivers KRAS and BRAF that has long been pursued as a drug target in oncology(1), and more recently in immunotherapy(2,3) and aging(4). However, many MEK inhibitors (MEKi) are limited due to on-target toxicities(5–7) and drug resist...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Khan, Zaigham M., Real, Alexander M., Marsiglia, William M., Chow, Arthur, Duffy, Mary E., Yerabolu, Jayasudhan R., Scopton, Alex P., Dar, Arvin C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746607/
https://ncbi.nlm.nih.gov/pubmed/32927473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2760-4
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