The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic reprogramming. Herein, we report that limiting PKM2 di...

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Detalles Bibliográficos
Publicado en:Blood
Autores principales: Nayak, Manasa K., Ghatge, Madankumar, Flora, Gagan D., Dhanesha, Nirav, Jain, Manish, Markan, Kathleen R., Potthoff, Matthew J., Lentz, Steven R., Chauhan, Anil K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2021
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995287/
https://ncbi.nlm.nih.gov/pubmed/33027814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007140
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