The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic reprogramming. Herein, we report that limiting PKM2 di...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Nayak, Manasa K., Ghatge, Madankumar, Flora, Gagan D., Dhanesha, Nirav, Jain, Manish, Markan, Kathleen R., Potthoff, Matthew J., Lentz, Steven R., Chauhan, Anil K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2021
Konular:
Thrombosis and Hemostasis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995287/
https://ncbi.nlm.nih.gov/pubmed/33027814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007140
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