The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic reprogramming. Herein, we report that limiting PKM2 di...

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Bibliographic Details
Published in:Blood
Main Authors: Nayak, Manasa K., Ghatge, Madankumar, Flora, Gagan D., Dhanesha, Nirav, Jain, Manish, Markan, Kathleen R., Potthoff, Matthew J., Lentz, Steven R., Chauhan, Anil K.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2021
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995287/
https://ncbi.nlm.nih.gov/pubmed/33027814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007140
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