Metabolic support of tumor-infiltrating regulatory T cells by lactic acid

Regulatory T (T(reg)) cells, vital for maintaining immune homeostasis, also represent a major barrier to cancer immunity, as the tumor microenvironment (TME) promotes T(reg) cell recruitment, differentiation, and activity(1,2). Tumor cells have deregulated metabolism leading to a metabolite-depleted...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Watson, McLane J., Vignali, Paolo D.A., Mullett, Steven J., Overacre-Delgoffe, Abigail E., Peralta, Ronal M., Grebinoski, Stephanie, Menk, Ashley V., Rittenhouse, Natalie L., DePeaux, Kristin, Whetstone, Ryan D., Vignali, Dario A. A., Hand, Timothy W., Poholek, Amanda C., Morrison, Brett M., Rothstein, Jeffrey D., Wendell, Stacy G., Delgoffe, Greg M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990682/
https://ncbi.nlm.nih.gov/pubmed/33589820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03045-2
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