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Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic, and metabolic characteristics. However, drivers of exhaustion remain poorly understood. As intratumoral exhausted T cells experience severe hypoxia, we hypothesized metabolic s...
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Vydáno v: | Nat Immunol |
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Hlavní autoři: | , , , , , , , , , , , |
Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
2021
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7971090/ https://ncbi.nlm.nih.gov/pubmed/33398183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-00834-9 |
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