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Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic, and metabolic characteristics. However, drivers of exhaustion remain poorly understood. As intratumoral exhausted T cells experience severe hypoxia, we hypothesized metabolic s...

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Vydáno v:Nat Immunol
Hlavní autoři: Scharping, Nicole E., Rivadeneira, Dayana B., Menk, Ashley V., Vignali, Paolo D. A., Ford, B. Rhodes, Rittenhouse, Natalie L., Peralta, Ronal, Wang, Yiyang, Wang, Yupeng, DePeaux, Kristin, Poholek, Amanda C., Delgoffe, Greg M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971090/
https://ncbi.nlm.nih.gov/pubmed/33398183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-00834-9
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