Oncolytic viruses engineered to enforce leptin expression reprogram tumor-infiltrating T cell metabolism and promote tumor clearance

Immunotherapy can reinvigorate dormant responses to cancer, but response rates remain low. Oncolytic viruses, which replicate in cancer cells, induce tumor lysis and immune priming, but their immune consequences are unclear. We profiled the infiltrate of aggressive melanomas induced by oncolytic Vac...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Rivadeneira, Dayana B., DePeaux, Kristin, Wang, Yiyang, Kulkarni, Aditi, Tabib, Tracy, Menk, Ashley V., Sampath, Padmavathi, Lafyatis, Robert, Ferris, Robert L., Sarkar, Saumendra N., Thorne, Stephen H., Delgoffe, Greg M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903394/
https://ncbi.nlm.nih.gov/pubmed/31471106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.07.003
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