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Unveiling the “invisible” druggable conformations of GDP-bound inactive Ras
The prevalent view on whether Ras is druggable has gradually changed in the recent decade with the discovery of effective inhibitors binding to cryptic sites unseen in the native structures. Despite the promising advances, therapeutics development toward higher potency and specificity is challenged...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7980447/ https://ncbi.nlm.nih.gov/pubmed/33836610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024725118 |
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