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Unveiling the “invisible” druggable conformations of GDP-bound inactive Ras
The prevalent view on whether Ras is druggable has gradually changed in the recent decade with the discovery of effective inhibitors binding to cryptic sites unseen in the native structures. Despite the promising advances, therapeutics development toward higher potency and specificity is challenged...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7980447/ https://ncbi.nlm.nih.gov/pubmed/33836610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024725118 |
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