Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST

Plexiform neurofibromas (PN) are benign nerve sheath Schwann cell tumors characterized by biallelic mutations in the NF1 tumor suppressor gene. Atypical neurofibromas (ANF) show additional frequent loss of CDKN2A/Ink4a/Arf and may be precursor lesions of aggressive malignant peripheral nerve sheath...

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Udgivet i:Cancer Res
Main Authors: Chaney, Katherine E., Perrino, Melissa R., Kershner, Leah J., Patel, Ami V., Wu, Jianqiang, Choi, Kwangmin, Rizvi, Tilat A., Dombi, Eva, Szabo, Sara, Largaespada, David A., Ratner, Nancy
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968129/
https://ncbi.nlm.nih.gov/pubmed/32816910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1429
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