Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST

Plexiform neurofibromas (PN) are benign nerve sheath Schwann cell tumors characterized by biallelic mutations in the NF1 tumor suppressor gene. Atypical neurofibromas (ANF) show additional frequent loss of CDKN2A/Ink4a/Arf and may be precursor lesions of aggressive malignant peripheral nerve sheath...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Chaney, Katherine E., Perrino, Melissa R., Kershner, Leah J., Patel, Ami V., Wu, Jianqiang, Choi, Kwangmin, Rizvi, Tilat A., Dombi, Eva, Szabo, Sara, Largaespada, David A., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968129/
https://ncbi.nlm.nih.gov/pubmed/32816910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1429
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