Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST

The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear. It is hypothesized that many genetic changes are involved...

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Bibliografski detalji
Glavni autori: Keng, Vincent W., Watson, Adrienne L., Rahrmann, Eric P., Li, Hua, Tschida, Barbara R., Moriarity, Branden S., Choi, Kwangmin, Rizvi, Tilat A., Collins, Margaret H., Wallace, Margaret R., Ratner, Nancy, Largaespada, David A.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539440/
https://ncbi.nlm.nih.gov/pubmed/23319880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/620834
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