Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance

Genetic changes required for the formation and progression of human Schwann cell tumors remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several genes involved in canonical Wnt signaling as potential drivers of benign neurofibromas and malignant peripheral nerve sheath t...

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Detalhes bibliográficos
Main Authors: Watson, Adrienne L., Rahrmann, Eric P., Moriarity, Branden S., Choi, Kwangmin, Conboy, Caitlin B., Greeley, Andrew D., Halfond, Amanda L., Anderson, Leah K., Wahl, Brian R., Keng, Vincent W., Rizzardi, Anthony E., Forster, Colleen L., Collins, Margaret H., Sarver, Aaron L., Wallace, Margaret R., Schmechel, Stephen C., Ratner, Nancy, Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679355/
https://ncbi.nlm.nih.gov/pubmed/23535903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0081
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