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STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma
Plexiform neurofibroma, a benign peripheral nerve tumor, is associated with the biallelic loss of function of the NF1 tumor suppressor in Schwann cells. Here, we show that FLLL32, a small molecule inhibitor of JAK/STAT3 signaling, reduces neurofibroma growth in mice with conditional, biallelic delet...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461477/ https://ncbi.nlm.nih.gov/pubmed/30542122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0600-x |
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