STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma

Plexiform neurofibroma, a benign peripheral nerve tumor, is associated with the biallelic loss of function of the NF1 tumor suppressor in Schwann cells. Here, we show that FLLL32, a small molecule inhibitor of JAK/STAT3 signaling, reduces neurofibroma growth in mice with conditional, biallelic delet...

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Publicado en:Oncogene
Autores principales: Fletcher, Jonathan S., Springer, Mitchell G., Choi, Kwangmin, Jousma, Edwin, Rizvi, Tilat A., Dombi, Eva, Kim, Mi-Ok, Wu, Jianqiang, Ratner, Nancy
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461477/
https://ncbi.nlm.nih.gov/pubmed/30542122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0600-x
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