Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST

Plexiform neurofibromas (PN) are benign nerve sheath Schwann cell tumors characterized by biallelic mutations in the NF1 tumor suppressor gene. Atypical neurofibromas (ANF) show additional frequent loss of CDKN2A/Ink4a/Arf and may be precursor lesions of aggressive malignant peripheral nerve sheath...

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Publicado en:Cancer Res
Autores principales: Chaney, Katherine E., Perrino, Melissa R., Kershner, Leah J., Patel, Ami V., Wu, Jianqiang, Choi, Kwangmin, Rizvi, Tilat A., Dombi, Eva, Szabo, Sara, Largaespada, David A., Ratner, Nancy
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968129/
https://ncbi.nlm.nih.gov/pubmed/32816910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1429
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