WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas that cause significant mortality in adults with Neurofibromatosis Type 1 (NF1). We compared gene expression of growth factors in normal human nerves to MPNST and normal human Schwann cells (NHSC) to MPNST cell lines...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Thomson, Craig S., Pundavela, Jay, Perrino, Melissa, Coover, Robert A., Choi, Kwangmin, Chaney, Katherine E., Rizvi, Tilat A., Largaespada, David A., Ratner, Nancy
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217297/
https://ncbi.nlm.nih.gov/pubmed/34079083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01773-x
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