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AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis
The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively regulates the pathogenesis of EAE independent of inflammasome activation. AIM2 deficiency enhanced microglia activation and inf...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7961553/ https://ncbi.nlm.nih.gov/pubmed/33710283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201796 |
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