AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively regulates the pathogenesis of EAE independent of inflammasome activation. AIM2 deficiency enhanced microglia activation and inf...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Ma, Chunmei, Li, Sheng, Hu, Yingchao, Ma, Yan, Wu, Yuqing, Wu, Chunyan, Liu, Xue, Wang, Bingwei, Hu, Gang, Zhou, Jiawei, Yang, Shuo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961553/
https://ncbi.nlm.nih.gov/pubmed/33710283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201796
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