Opposing functions of microglial and macrophagic TNFR2 in the pathogenesis of experimental autoimmune encephalomyelitis

In multiple sclerosis (MS), soluble tumor necrosis factor (TNF) is detrimental via activation of TNF receptor 1 (TNFR1), whereas transmembrane TNF is beneficial primarily by activating TNF receptor 2 (TNFR2). Here we investigate the role of TNFR2 in microglia and monocytes/macrophages in experimenta...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Gao, Han, Danzi, Matt C., Choi, Claire S., Taherian, Mehran, Dalby-Hansen, Camilla, Ellman, Ditte G., Madsen, Pernille M., Bixby, John L., Lemmon, Vance P., Lambertsen, Kate L., Brambilla, Roberta
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218601/
https://ncbi.nlm.nih.gov/pubmed/28052249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.083
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