AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively regulates the pathogenesis of EAE independent of inflammasome activation. AIM2 deficiency enhanced microglia activation and inf...

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Опубликовано в: :J Exp Med
Главные авторы: Ma, Chunmei, Li, Sheng, Hu, Yingchao, Ma, Yan, Wu, Yuqing, Wu, Chunyan, Liu, Xue, Wang, Bingwei, Hu, Gang, Zhou, Jiawei, Yang, Shuo
Формат: Artigo
Язык:Inglês
Опубликовано: Rockefeller University Press 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961553/
https://ncbi.nlm.nih.gov/pubmed/33710283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201796
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