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AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis
The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively regulates the pathogenesis of EAE independent of inflammasome activation. AIM2 deficiency enhanced microglia activation and inf...
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| Publicat a: | J Exp Med |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Rockefeller University Press
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7961553/ https://ncbi.nlm.nih.gov/pubmed/33710283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201796 |
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