Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in the CNS of EAE...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Li, Sheng, Wu, Yuqing, Yang, Dongxue, Wu, Chunyan, Ma, Chunmei, Liu, Xue, Moynagh, Paul N., Wang, Bingwei, Hu, Gang, Yang, Shuo
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829591/
https://ncbi.nlm.nih.gov/pubmed/31467036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190377
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