Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in the CNS of EAE...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Exp Med
Hlavní autoři: Li, Sheng, Wu, Yuqing, Yang, Dongxue, Wu, Chunyan, Ma, Chunmei, Liu, Xue, Moynagh, Paul N., Wang, Bingwei, Hu, Gang, Yang, Shuo
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829591/
https://ncbi.nlm.nih.gov/pubmed/31467036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190377
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky