Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in the CNS of EAE...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Li, Sheng, Wu, Yuqing, Yang, Dongxue, Wu, Chunyan, Ma, Chunmei, Liu, Xue, Moynagh, Paul N., Wang, Bingwei, Hu, Gang, Yang, Shuo
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829591/
https://ncbi.nlm.nih.gov/pubmed/31467036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190377
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