Bortezomib suppresses self‐renewal and leukemogenesis of leukemia stem cell by NF‐ĸB‐dependent inhibition of CDK6 in MLL‐rearranged myeloid leukemia

Acute myeloid leukaemia (AML) with chromosomal rearrangements involving the H3K4 methyltransferase mixed‐lineage leukaemia (MLL) is an aggressive subtype with low overall survival. Bortezomib (Bort) is first applied in multiple myeloma. However, whether bort possesses anti‐self‐renewal and leukemoge...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Zhou, Bin, Qin, Yaqian, Zhou, Jingying, Ruan, Jichen, Xiong, Fang, Dong, Jinglai, Huang, Xingzhou, Yu, Zhijie, Gao, Shenmeng
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957264/
https://ncbi.nlm.nih.gov/pubmed/33599085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16377
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