Bortezomib suppresses self‐renewal and leukemogenesis of leukemia stem cell by NF‐ĸB‐dependent inhibition of CDK6 in MLL‐rearranged myeloid leukemia

Acute myeloid leukaemia (AML) with chromosomal rearrangements involving the H3K4 methyltransferase mixed‐lineage leukaemia (MLL) is an aggressive subtype with low overall survival. Bortezomib (Bort) is first applied in multiple myeloma. However, whether bort possesses anti‐self‐renewal and leukemoge...

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Pubblicato in:J Cell Mol Med
Autori principali: Zhou, Bin, Qin, Yaqian, Zhou, Jingying, Ruan, Jichen, Xiong, Fang, Dong, Jinglai, Huang, Xingzhou, Yu, Zhijie, Gao, Shenmeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957264/
https://ncbi.nlm.nih.gov/pubmed/33599085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16377
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