Bortezomib suppresses self‐renewal and leukemogenesis of leukemia stem cell by NF‐ĸB‐dependent inhibition of CDK6 in MLL‐rearranged myeloid leukemia

Acute myeloid leukaemia (AML) with chromosomal rearrangements involving the H3K4 methyltransferase mixed‐lineage leukaemia (MLL) is an aggressive subtype with low overall survival. Bortezomib (Bort) is first applied in multiple myeloma. However, whether bort possesses anti‐self‐renewal and leukemoge...

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Detaylı Bibliyografya
Yayımlandı:J Cell Mol Med
Asıl Yazarlar: Zhou, Bin, Qin, Yaqian, Zhou, Jingying, Ruan, Jichen, Xiong, Fang, Dong, Jinglai, Huang, Xingzhou, Yu, Zhijie, Gao, Shenmeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2021
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957264/
https://ncbi.nlm.nih.gov/pubmed/33599085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16377
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