Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia

Cyclin-dependent kinase 9 and bromodomain and extraterminal inhibitors are synergistic in MLL-rearranged leukemia. Multiple AML driver genes are downregulated by the combined therapy suggesting broad applicability for this subtype.

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: McCalmont, Hannah, Li, Ka Leung, Jones, Luke, Toubia, John, Bray, Sarah C., Casolari, Debora A., Mayoh, Chelsea, Samaraweera, Saumya E., Lewis, Ian D., Prinjha, Rab K., Smithers, Nicholas, Wang, Shudong, Lock, Richard B., D’Andrea, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Stimulus Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988396/
https://ncbi.nlm.nih.gov/pubmed/31971998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000586
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados