Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia

Cyclin-dependent kinase 9 and bromodomain and extraterminal inhibitors are synergistic in MLL-rearranged leukemia. Multiple AML driver genes are downregulated by the combined therapy suggesting broad applicability for this subtype.

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Podrobná bibliografie
Vydáno v:Blood Adv
Hlavní autoři: McCalmont, Hannah, Li, Ka Leung, Jones, Luke, Toubia, John, Bray, Sarah C., Casolari, Debora A., Mayoh, Chelsea, Samaraweera, Saumya E., Lewis, Ian D., Prinjha, Rab K., Smithers, Nicholas, Wang, Shudong, Lock, Richard B., D’Andrea, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Stimulus Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988396/
https://ncbi.nlm.nih.gov/pubmed/31971998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000586
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