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PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice
Inhibitors of cAMP-phosphodiesterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular emesis and nausea, have curbed their clinical utility. Here, we show that PAN-selective inhibition of PDE4, but not inhibition of PDE3, causes a time- and dose-dependent...
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| 出版年: | FASEB J |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954513/ https://ncbi.nlm.nih.gov/pubmed/32738081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001016RR |
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