PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

Inhibitors of cAMP-phosphodiesterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular emesis and nausea, have curbed their clinical utility. Here, we show that PAN-selective inhibition of PDE4, but not inhibition of PDE3, causes a time- and dose-dependent...

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Detaylı Bibliyografya
Yayımlandı:FASEB J
Asıl Yazarlar: McDonough, Will, Aragon, Ileana V., Rich, Justin, Murphy, James M., Saleh, Lina Abou, Boyd, Abigail, Koloteva, Anna, Richter, Wito
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954513/
https://ncbi.nlm.nih.gov/pubmed/32738081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001016RR
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