Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice

Despite major advances, there remains a need for novel anesthetic drugs or drug combinations with improved efficacy and safety profiles. Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4), while not inducing anesthesia by itself, potently enhances the anesthetic effects of Isoflurane i...

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Détails bibliographiques
Publié dans:Biochem Pharmacol
Auteurs principaux: Aragon, Ileana V., Boyd, Abigail, Abou Saleh, Lina, Rich, Justin, McDonough, Will, Koloteva, Anna, Richter, Wito
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052286/
https://ncbi.nlm.nih.gov/pubmed/33609559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2021.114477
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