Inhibition of Type 4 cAMP-phosphodiesterases (PDE4s) in mice induces hypothermia via effects on behavioral and central autonomous thermoregulation

Inhibitors of Type 4 cAMP-phosphodiesterases (PDE4s) exert a number of promising therapeutic benefits, including potent anti-inflammatory, memory- and cognition-enhancing, metabolic, and antineoplastic effects. We report here that treatment with a number of distinct PDE4 inhibitors, including Rolipr...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: McDonough, Will, Rich, Justin, Aragon, Ileana V., Saleh, Lina Abou, Boyd, Abigail, Richter, Aris, Koloteva, Anna, Richter, Wito
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606724/
https://ncbi.nlm.nih.gov/pubmed/32702371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114158
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