PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

Inhibitors of cAMP-phosphodiesterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular emesis and nausea, have curbed their clinical utility. Here, we show that PAN-selective inhibition of PDE4, but not inhibition of PDE3, causes a time- and dose-dependent...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: McDonough, Will, Aragon, Ileana V., Rich, Justin, Murphy, James M., Saleh, Lina Abou, Boyd, Abigail, Koloteva, Anna, Richter, Wito
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954513/
https://ncbi.nlm.nih.gov/pubmed/32738081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001016RR
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