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Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue

Cyclic nucleotide PDE4 (phosphodiesterase 4) inhibitors are being developed as potent anti-inflammatory drugs for use in chronic lung diseases, but the complexity of the PDE4 family has hampered this process. The four genes comprising the PDE4 family, PDE4A, PDE4B, PDE4C and PDE4D, are all expressed...

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Detalhes bibliográficos
Main Authors: Richter, Wito, Jin, S.-L. Catherine, Conti, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183459/
https://ncbi.nlm.nih.gov/pubmed/15717866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050030
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