Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses

Lipopolysaccharide (LPS) stimulation of the innate immune response requires the activation of signaling cascades that culminate in the synthesis and secretion of proinflammatory cytokines. Given the inhibitory effects of phosphodiesterase (PDE) inhibitors on LPS-induced cytokine production, we have...

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Bibliographische Detailangaben
Hauptverfasser: Jin, S.-L. Catherine, Conti, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124305/
https://ncbi.nlm.nih.gov/pubmed/12032334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122041599
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