Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses

Lipopolysaccharide (LPS) stimulation of the innate immune response requires the activation of signaling cascades that culminate in the synthesis and secretion of proinflammatory cytokines. Given the inhibitory effects of phosphodiesterase (PDE) inhibitors on LPS-induced cytokine production, we have...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Jin, S.-L. Catherine, Conti, Marco
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2002
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032334/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122041599
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