Cyclic Nucleotide Phosphodiesterase Families as Targets to Treat Pulmonary Arterial Hypertension: Beyond PDE5 Inhibitors?

Pulmonary arterial hypertension (PAH) is a fatal disease with no cure. Until recently, most specific therapies for PAH had aimed at enhancing cyclic nucleotide (cAMP and cGMP) pathways, taking advantage of the vasorelaxant and antiproliferative properties of these key intracellular messengers. This...

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Hlavní autoři:	Liting Wang, Rodolphe Fischmeister, Boris Manoury
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-10-01
Edice:	Cells
Témata:	phosphodiesterases pulmonary arterial hypertension cAMP cGMP pharmacological therapies
On-line přístup:	https://www.mdpi.com/2073-4409/14/21/1670
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