MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease

Sickle cell disease (SCD) is associated with hemolysis, vascular inflammation, and organ damage. Affected patients experience chronic painful vaso-occlusive events requiring hospitalization. Hypoxia-induced polymerization of sickle hemoglobin S (HbS) contributes to sickling of red blood cells (RBCs)...

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Bibliografiset tiedot
Julkaisussa:Blood Adv
Päätekijät: Demers, Melanie, Sturtevant, Sarah, Guertin, Kevin R., Gupta, Dipti, Desai, Kunal, Vieira, Benjamin F., Li, Wenjing, Hicks, Alexandra, Ismail, Ayman, Gonçalves, Bronner P., Di Caprio, Giuseppe, Schonbrun, Ethan, Hansen, Scott, Musayev, Faik N., Safo, Martin K., Wood, David K., Higgins, John M., Light, David R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2021
Aiheet:
Red Cells, Iron, and Erythropoiesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948285/
https://ncbi.nlm.nih.gov/pubmed/33661300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003670
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