MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes

Inhibitors of methionine aminopeptidase 2 (MetAP2) have been shown to reduce body weight in obese mice and humans. The target tissue and cellular mechanism of MetAP2 inhibitors, however, have not been extensively examined. Using compounds with diverse chemical scaffolds, we showed that MetAP2 inhibi...

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Publicado en:J Biol Chem
Autores principales: Huang, Huey-Jing, Holub, Corine, Rolzin, Paul, Bilakovics, James, Fanjul, Andrea, Satomi, Yoshinori, Plonowski, Artur, Larson, Christopher J., Farrell, Pamela J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579473/
https://ncbi.nlm.nih.gov/pubmed/31048375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007302
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