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The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of solid tumors. The leading anti-angiogenic compound, TNP-470, has proven to be effective in in vitro and in animal model studies, and is currently being tested in phase III an...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Sin, Ny, Meng, Lihao, Wang, Margaret Q. W., Wen, James J., Bornmann, William G., Crews, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21008/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9177176/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.12.6099
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