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The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of solid tumors. The leading anti-angiogenic compound, TNP-470, has proven to be effective in in vitro and in animal model studies, and is currently being tested in phase III an...

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Bibliografische gegevens
Hoofdauteurs: Sin, Ny, Meng, Lihao, Wang, Margaret Q. W., Wen, James J., Bornmann, William G., Crews, Craig M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences of the USA 1997
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21008/
https://ncbi.nlm.nih.gov/pubmed/9177176
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