MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

Fumagillin and its derivatives are therapeutically useful because they can decrease cancer progression. The specific molecular target of fumagillin is methionine aminopeptidase 2 (MetAP2), one of the two MetAPs present in the cytosol. MetAPs catalyze N-terminal methionine excision (NME), an essentia...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Frottin, Frédéric, Bienvenut, Willy V., Bignon, Jérôme, Jacquet, Eric, Jacome, Alvaro Sebastian Vaca, Van Dorsselaer, Alain, Cianferani, Sarah, Carapito, Christine, Meinnel, Thierry, Giglione, Carmela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325365/
https://ncbi.nlm.nih.gov/pubmed/27542228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11216
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