MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

Fumagillin and its derivatives are therapeutically useful because they can decrease cancer progression. The specific molecular target of fumagillin is methionine aminopeptidase 2 (MetAP2), one of the two MetAPs present in the cytosol. MetAPs catalyze N-terminal methionine excision (NME), an essentia...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Frottin, Frédéric, Bienvenut, Willy V., Bignon, Jérôme, Jacquet, Eric, Jacome, Alvaro Sebastian Vaca, Van Dorsselaer, Alain, Cianferani, Sarah, Carapito, Christine, Meinnel, Thierry, Giglione, Carmela
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325365/
https://ncbi.nlm.nih.gov/pubmed/27542228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11216
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