MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes

Inhibitors of methionine aminopeptidase 2 (MetAP2) have been shown to reduce body weight in obese mice and humans. The target tissue and cellular mechanism of MetAP2 inhibitors, however, have not been extensively examined. Using compounds with diverse chemical scaffolds, we showed that MetAP2 inhibi...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Huang, Huey-Jing, Holub, Corine, Rolzin, Paul, Bilakovics, James, Fanjul, Andrea, Satomi, Yoshinori, Plonowski, Artur, Larson, Christopher J., Farrell, Pamela J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579473/
https://ncbi.nlm.nih.gov/pubmed/31048375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007302
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