MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease

Sickle cell disease (SCD) is associated with hemolysis, vascular inflammation, and organ damage. Affected patients experience chronic painful vaso-occlusive events requiring hospitalization. Hypoxia-induced polymerization of sickle hemoglobin S (HbS) contributes to sickling of red blood cells (RBCs)...

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Foilsithe in:Blood Adv
Main Authors: Demers, Melanie, Sturtevant, Sarah, Guertin, Kevin R., Gupta, Dipti, Desai, Kunal, Vieira, Benjamin F., Li, Wenjing, Hicks, Alexandra, Ismail, Ayman, Gonçalves, Bronner P., Di Caprio, Giuseppe, Schonbrun, Ethan, Hansen, Scott, Musayev, Faik N., Safo, Martin K., Wood, David K., Higgins, John M., Light, David R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2021
Ábhair:
Red Cells, Iron, and Erythropoiesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948285/
https://ncbi.nlm.nih.gov/pubmed/33661300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003670
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